eLife

Compensation of hyperexcitability with simulation-based inference

Simulation-based inference predicts putative circuit mechanisms of hyperexcitability in a phenomenological microcircuit ...
BIOENGINEER

AI Model Scores College Spoken English With 95 Percent Accuracy

A new open-access study reports an AI and IoT-based system that classifies college spoken English performance with 95.47 ...
Science

Graph-based pangenome analysis uncovers structural and functional impacts of allopolyploidization events

The emergence of graph pangenomes has advanced the study of structural variants (SVs) across diverse species, yet the impact of complex ploidy on SV landscapes remains poorly explored. Brettanomyces ...
Science

Cas9 nickase–mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington’s disease mouse model

Cas9 nickase contracts CAG/CTG repeats in Huntington’s disease patient–derived medium spiny neurons and in a mouse disease model.